Effective Concentration of Mitomycin-C in Surgery for Primary Pterygium

The recurrent rate after pterygium surgery is about 30 to 50%and mitomycin-C has been used as soaking method during surgery or as instillation after surgery for reduction of the recurrence. To determine the effective concentration of mitomycin-C in soaking method during pterygium surgery, we reviewed 87 patients(95 eyes)who were divided into three groups with different concentrations of MMC. The application time was 5 minute and concentration of MMC was 0.1 mg/ml(n=31), 0.2 mg/ml(n=35), and 0.4 mg/ml(n=29), respectively. During the mean follow-up period of 8 months, recurrent rate was 16.1%(5eyes)in 0.1mg/ml group, 14.3%(5 eyes)in 0.2 mg/ml, and 13.8%(4 eyes)in 0.4 mg/ml group. This difference was not statistically significant(p>0.05). Complication rate was 6.5%(2 eyes)in 0.1 mg/ml group, 8.6%(3 eyes)in 0.2 mg/ml group, and 10.3%(3 eyes)in 0.4 mg/ml group;these results were also not statistically significant(p>0.05). In conclusion, it is desirable to use lower concentration of MMC in soaking method for prevention of the recurrence of primary pterygium surgery.

Clinical Observation of Intrathecal Meperidine Anesthesia and the Effect of Added Epinephrine / 대한마취과학회지

Intrathecal meperidine produces a profound analgesia, because meperidine has a high lipid solubility and a structure similar to local anesthetics. This study was undertaken to evaluate the anesthetic effect and complications of intrathecal meperidine anesthesia and the effect of added epinephrine. Two percent meperidine 30 mg (Group I) and 2% meperidine 30 mg with 0.3 mg epinephrine (Group II) in 20% D/W were injected intrathecally in each of 30 cases scheduled for simple and short surgical procedures. The results are as follows: 1) Systolic blood pressure and pulse rate decreased significantly from 10 minutes to 1 hour after intrathecal meperidine injection, compared with the value before anesthetic administration, but did not require special medical treatment. 2) The onset time of block of T, sensory dermatome in the meperidine injection group (Group 1) and the added epinephrine mixed injection group (Group II), were 5.3+/-1.4 minutes and 6.6+/-2.1 minutes, and duration were 58.5+/-10.5 minutes and 74.1+/-16.4 minutes respectively. Therefore, the onset time of motor nerve blok were 5.5+/-2.6 minutes and 8.9+/-1.6 minutes, and then their duration were 65.7+/-11.4 minutes and 79.7+/-13.4 minutes respectively. 3) PaO decreased and PaCO2 increased significantly 1 hour after meperidine injection without any serious problem. 4) Complications, such as nausea, pruritus and urinary retention, were observed in many patients without any serious problem.